Live For Live Music: With so many songwriters in Fruition, I always wonder how much of a scrum the sessions are. How many songs did you have to choose from for the new album?Jay Cobb Anderson: It was difficult. There were a lot of songs on the table. In the past, we’ve tried to split it up more equally so you heard from each songwriter. For this album we wanted to pick all of the songs we felt the strongest about. I ended up having more songs on this record than the others, but we think these songs fit together the best and were the strongest. This was an especially difficult one though.L4LM: Have you guys considered a double or even a triple album?JCA: Absolutely. Seeing how this one goes…that may end up happening for the next record. We have so much material. That said, another thing we want to do is get a live record out there too. We might end up putting two things out, a live record and an LP. We’ll see.L4LM: I feel like you have a rabid-enough fan base that you could put out two records a year, easily.JCA: I totally agree with you. That’s the thing with being self-promoted. Our whole goal as a band has been to build a strong enough team, including funding, to be able to put out records as much as we would like. That’s been difficult. But we did just sign on with LoHi Records, and this whole experience working with them has been great. We loved working with them. They love us. Watching It All Fall Apart, the new record, it’s a product of that love.With that love in mind, we are already starting to think of stuff for a new album, like I said. We hope this is the start of a long and successful friendship. We’re really excited about that. The way the music industry works now, everything is on you. We want to make more music, but when it’s all on you it’s a lot more difficult.L4LM: Tim Carbone (Railroad Earth) and his partners really seem to have put something wonderful together with LoHi Records. Did you get to work with Tim on Watching It All Fall Apart?JCA: He didn’t work on the record itself, but he was the catalyst for us joining on LoHi. He sat in with us at the Hillberry Music Festival, and when we got done with our set he asked us what we planned on doing with our new material. That was about the same time when we were considering what to do ourselves. He listened to what we had and said he loved it and invited us to work with LoHi.It was perfect timing. We had been shopping around for a home for the music and hadn’t found any offers we liked. Then we chatted with the crew at LoHi and it evolved into what it is now. And we’re really stoked.Fruition – “Labor Of Love” – Northwest String Summit – 7/12/17[Video: Live For Live Music]L4LM: When writing songs do you ever have moments where you think…”This is it, this is one of the good ones,” or even the opposite like, say, “This blows. No one is gonna dig this at all.” If so, how often are you right?JCA: Absolutely! It’s funny. A lot of the time I get it wrong. Our first single, “I’ll Never Sing Your Name”, wasn’t even on the table for the new record. I thought it was just this little crappy song that I wrote and it ended up being the first single.That happened in the past too…on our album Just One Of Them Nights, I thought the title track was no good at all. Then I played a solo show with my buddy Brad Parsons and he was like “Where did that song come from?” I said something dismissive and he was like, “No man, you need to play that. You need to play that for your band!” And then it became the title track of that album. So I guess I’m not that good at predicting…L4LM: How many shows did Fruition play last year?JCA: Oh god, I have no idea. At least 150. Probably closer to 200.L4LM: Are you folks looking to match the same pace this year?JCA: Oh yeah. We’re on the first leg of a two-and-a-half month tour. I think we’re doing five weeks, taking ten days off, then another five. Then, for spring into the summer we start doing all the one-offs, week-long runs and, of course, the festivals!L4LM: The glorious festivals!JCA: YES!L4LM: When Fruition gets going, you front-line folks have been known to slam around the stage in an almost basketball team-style weave. Ever slip up and slam into each other when you get all caught up in the music?JCA: Oh yeah. A lot of that energy you see, at least like what you are describing, started out in our origins as a busking band. When you’re out on the street playing for cash and trying to get attention, you tend to move around a lot. So much of that stuff, like our movement, comes from that era. Most of the worst instances of banging into each other happened back then…Once we started playing on stages, we got to the point where we had a lot more room. Luckily most of the stages these days give us enough room.L4LM: You gotta watch out for Mimi…she looks like she could take you out with those elbows.JCA: I worry mostly about me and my lanky self.Fruition – “Hey Hey What Can I Do” (Led Zeppelin cover) – Hoxeyville Music Festival – 8/19/17:[Video: Live For Live Music]L4LM: Your live performances are exhausting to watch, but damn exciting too. Do you feel like the new record captures that live Fruition vibe?JCA: Most of the songs that we recorded for this disc are ones we hadn’t played live. It was fun to try and translate that energy into them. I do think this one captures the energy better. The song “I’ll Never Sing Your Name” [on the album] was recorded totally live. There are a couple of tunes on this record that were recorded almost completely in-the-moment.L4LM: Do you feel like the zeitgeist influences your songwriting? The world is getting kinda weird and harsh lately…JCA: I think with this album it definitely did. Like you said…it’s a strange world out there. There’s no big social commentary on this album, but I think Watching It All Fall Apart kinda works for a title and a description of the way the world seems sometimes.We want to make more of a political statement, but you have to be careful. It seems one of the big problems is the splitting along lines and the dividing that is happening among people being so hard on one side or the other. We don’t want to make that gap bigger…we want to bring people together.For a full list of upcoming Fruition tour dates, head to the band’s website. You can listen to their new album, Watching It All Fall Apart, below via Spotify:Fruition – Watching It All Fall Apart[Cover photo via Sam Shinault] Over the past year, Fruition has seen their stardom rise on a national scale, slowly but steadily climbing up the bills of renowned music festivals and performing at iconic venues like Colorado’s Red Rocks Amphitheatre. We caught up with Fruition lead guitarist Jay Cobb Anderson as he prepared to load in for a gig in Kansas the same week the band’s released their newest disc, Watching It All Fall Apart. The life of a touring musician may be a dream come true, but no one ever claimed it was easy. Even with all that going on, Jay was more than happy to talk about the stellar selection of new tunes on Fruition’s new album and the process the band went through to composing and selecting the tracks.
Treatment with inhaled nitric oxide (NO) has proved to be lifesaving in newborns, children, and adults with several dangerous conditions. But the availability of the treatment has been limited by the size, weight, and complexity of equipment needed to administer the gas, and the therapy’s high price.Now a research team led by Warren M. Zapol, the Reginald Jenney Professor of Anaesthesia at Harvard Medical School and Massachusetts General Hospital (MGH), has developed a lightweight, portable system that produces NO from the air by means of an electrical spark. Zapol, who pioneered the use of inhaled nitric oxide, is the senior author of a report on the system, which is described by MGH investigators in the July 1 issue of Science Translational Medicine.“Nitric oxide is used to treat about 35,000 hospitalized U.S. patients each year — mostly adults with pulmonary hypertension and infants with a condition called persistent pulmonary hypertension of the newborn (PPHN),” said Zapol, director of the MGH Anesthesia Center for Critical Care Research and emeritus chief of anesthesia and critical care at the hospital.“But NO therapy is very expensive — here at MGH, five days’ treatment of a newborn with PPHN costs around $14,000 — and current systems use gas delivered in heavy tanks, making ambulatory treatment impractical,” he explained. “Our new system can economically make NO from the nitrogen and oxygen in the air using only small amounts of electric power. This device could enable trials of NO to treat patients with chronic lung diseases and certain kinds of heart failure, and would make NO therapy available in parts of the world that don’t have the resources that are currently required.”Not to be confused with the anesthetic gas nitrous oxide, nitric oxide was long considered to be only a toxic pollutant gas. But in the mid-1980s, three U.S. investigators discovered that NO is a signal-transmitting molecule naturally used by the pulmonary, cardiac, and other systems — a discovery that received the 1998 Nobel Prize. Among its many functions, NO relaxes muscles surrounding blood vessels, which reduces blood pressure — a property that led Zapol and his colleagues to investigate its use to treat hypertension in vessels supplying the lungs. Their discovery that inhaled NO selectively relaxed pulmonary vessels without producing a systemic drop in blood pressure led to the therapy’s FDA approval in 1999 for the treatment of PPHN and other lung diseases in newborns. In 2003, Zapol and his former research fellow Claes Frostell received the Inventor of the Year award from the Intellectual Property Owners Association for the development of a system to safely deliver inhaled NO.Since its FDA approval, NO has been supplied to hospitals in large tanks of compressed gas and administered through bulky and complex delivery devices by trained respiratory therapists. However, in 1992, Zapol and MGH were issued a patent for a system his team had developed to produce NO — which can be naturally produced by lightning bolts — from air by means of an electrical spark.Although the discovery was licensed by two medical and industrial gas companies, the technology was never developed, possibly because the medical use of inhaled NO was only beginning to be accepted. In addition, the system originally invented by the MGH team was still too large for use in outpatient settings. The growing therapeutic use of NO — along with technological advances including the availability of miniaturized electronic circuitry — allowed the MGH team to develop the system described in the current report.The investigators designed and built two prototype systems: in one, the NO generator is a separate “offline” system continually generating gas that is delivered into a ventilation system via tubing; the second, an “inline” system, is incorporated into the ventilation system in a way that synchronizes the generation of NO during inhalation with the pulsed delivery of oxygen and other gases to be inhaled, reducing the NO that would be lost during exhalation. Because generation of NO by an electric spark can also produce the toxic gases nitrogen dioxide and ozone, along with metal fragments from the electrode, both systems use calcium hydroxide and air filters to absorb and remove those byproducts.A series of experiments helped the team determine the best metal to use for the electrode — iridium — and the optimal timing and number of electric sparks. Testing in an animal model revealed that the electrically generated NO produced by both systems was as effective as tank-delivered gas in relieving pulmonary hypertension. Although a gas mixture containing 50 percent oxygen produced the highest NO levels, the amount produced from ambient air was sufficient for therapeutic use. Both systems continued to deliver therapeutic levels of NO for up to 10 days, and subsequent experiments with the inline system not included in this report have continued for up to 28 days. There’s no reason to think the system could not stably produce NO for even longer periods of time, noted Zapol.“It’s amazing how long this system continues to make NO,” he said. “Once we’ve shown that this [system] can safely be used in human patients with pulmonary hypertension — and we’ve got a clinical trial in progress right now — we’ll be able to conduct studies of inhaled NO delivered in ambulatory settings, including patients’ homes, to treat chronic pulmonary hypertension, right-sided heart failure, and chronic obstructive pulmonary disease.”