Ranking the difficulty of OSU’s remaining schedule

first_imgIf you’re looking for the comments section, it has moved to our forum, The Chamber. You can go there to comment and holler about these articles, specifically in these threads. You can register for a free account right here and will need one to comment.If you’re wondering why we decided to do this, we wrote about that here. Thank you and cheers! Oklahoma State has one of the nation's toughest schedules the rest of the way (USATSI)Oklahoma State has one of the nation’s toughest schedules the rest of the way (USATSI)First and foremost, I should start by saying last weekend was pure insanity in college football. Big games, upsets, goal posts being torn down by massive crowds of Red Bull infused students… it was amazing.As for myself, I watched everything unfold with a group of friends I was visiting in Dallas. There’s really no substitute for watching big games in unfamiliar territories with fans of different teams.As you can imagine, the bar I was in/the state of Texas was pretty stoked when TCU pulled off the upset against OU. As a lifelong Okie, I should probably be less excited when the Sooners lose…but I was right there celebrating with strangers in Horned Frog t-shirts. It was during this activity that I was shaken to my core.At a table across the bar sat an older couple—probably both in their 60s, just taking in the excitement of a massive win. I approached this seemingly harmless duo with a smile on my face, excitedly telling them, “I went to Oklahoma State and I just want to say thank you for what just happened!” I was sincere in my appreciation, yet entirely unprepared for what followed.Without skipping a beat, the older gentlemen looked me in the eye and said, “Talk to me in two weeks and let’s see how you feel about us then.”I’m serious. He said that to me.I pride myself on my wit, okay? I’m typically ready for just about anything. But in this moment, in a random bar in Dallas, an old man in a purple shirt caught me completely off guard and ruined me. Took me to the old school and gave me an education. I returned to Oklahoma a broken man.But with his advice in mind, I began thinking about the seven games left on our schedule and decided to rank them based on the expected difficulty level.While I only wish I could revisit that situation (I’ve come up with 8,348 comebacks I should have said), the only level of revenge I can have here is knowing I’m not most worried about TCU.So take that.7. Kansas: This weekend at KansasKansas is 2-3 so far and strikes about as much fear into my heart as a kitten. I refuse to fear a team with Montell Cozart at QB. (Don’t make me regret such a strong stance, Cowboys)6: Texas: Nov. 15 at BPSVince Young’s not walking through that door. Colt McCoy’s not walking through that door. Mack Brown’s not walking through that door…5. West Virginia: Oct. 25 at BPSThis is clearly one of those games we should start worrying about, as West Virginia played OU and Alabama incredibly well. Really just glad this game is at home, and hopefully the team is still upset about last season.Because I am.4. Kansas State: Nov. 1 at Kansas StateWe’ve jumped them in the polls, but this is a terrifying game to play in Manhattan. Looked all over for a silver lining…luckily found this one: They only beat Iowa State by four points. Take what you can get.3. TCU: Oct. 18 at TCUI don’t know if I actually fear TCU more than K-State, or if the old man is still in my head. Regardless, this is a top 10 team and Trevone Boykin is apparently the real deal. Worried about what he can do with his feet against the Cowboy defense.2. Baylor: Nov. 22 at BaylorThings I don’t want to do: Go to the dentist, go grocery shopping, go to Waco to play the Bears. Something tells me they’re still upset about last season…but last season gives me hope, as well.1. OU: Dec. 6 at OUI get that OU lost to TCU and now everyone knows it’s possible…but this is a really good OU football team. To make matters worse, we have to travel to Norman to attempt the upset bid.I’m putting my eggs in the “Have Boone Pickens offer Katy Perry a large amount of money to ruin Trevor Knight’s life” basket. But we could also beat them straight up, sure.That works too.Totally Tickets is your source for Oklahoma State football tickets.last_img read more

Videos: Louisville Owned SportsCenter’s Top 10 Plays After Dominating Syracuse

first_imgDonovan Mitchell throws down dunk against Syracuse..Twitter/@theACCDNMidway through the second half of Wednesday night’s 72-58 home win over Syracuse, the Louisville Cardinals were doing whatever they wanted on offense. The dominant display was heavily featured on SportsCenter this morning, where the Cardinals had three of the Top 10 plays of the day.First up, at No. 7, this beautiful behind-the-back assist by Chinanu Onuaku.Nanu droppin’ dimes. pic.twitter.com/7MFnoY0qRb— LouisvilleSportsLive (@LvilleSprtsLive) February 18, 2016Next, at No. 4, another Onuaku assist—this time to Jaylen Johnson for a powerful alley-oop.It’s like Louisville found a “if you make the other team cry they have to let you play in the tournament” loophole pic.twitter.com/m4kMWmXva4— Mike Rutherford (@CardChronicle) February 18, 2016And finally, Louisville took home the top play, with this ferocious alley-oop from Damion Lee to Donovan Mitchell.If you look close enough, you can see a smile on Donovan Mitchell’s face as he slams this one home for @GoCards!https://t.co/xlTSYEXZ08— ACC Digital Network (@theACCDN) February 18, 2016That one was just mean. Mitchell liked it so much, he made it the header photo for his Twitter profile. donovan mitchell twitterIt’s been a rough few weeks for the Cardinals. Last night’s big win had to be pretty cathartic.last_img read more

STARTERS ORDERS Tuesday

first_img[dropcap]W[/dropcap]elcome to Starters Orders. Our daily midday update from the trading room at Star Sports with our key market movers for the day across all sports.Tuesday 28 February HORSE RACINGCLICK HERE FOR OUR CHELTENHAM 2017 ANTEPOST PRICES3.00 LingfieldSennockian Star 7/2 > 5/23.10 TowcesterToby Lerone 7/2 > 5/24.00Pinwood 7/2 > 5/2 Light Of Air 7/1 > 9/24.40 LeicesterThe Highlander 6/5 > 4/5LIVE FOOTBALLScottish Premiership19:45 BT Sport 1 / BT Sport 1 HD6/1 Hamilton Academical 1/2 Aberdeen 3/1 DRAWChampionship19:45 Sky Sports 1 / Sky Sports 1 HD6/4 Brighton & Hove Albion 21/10 Newcastle United 11/5 DRAWBET WITH STAR SPORTS 08000 521 321last_img read more

Shorter course of trastuzumab could be an option for women with HER2

first_img low risk (pathologic tumour size [pT] < 2cm and N0), accounting for 37.5% of patients intermediate risk (pT < 2cm and any N category), accounting for 51.9% high risk (pT > 2cm and N4+), accounting for 10.5% of the patient population. Results showed that patients with low and intermediate risk had similar five-year DFS with a nine-week course of trastuzumab (88%) as with one year (89%; hazard ratio 1.02, 95% confidence interval [CI] 0.78-1.33) but their risk of cardiac events was nearly three times lower (4.5% vs 12.8%, relative risk 2.88 95% CI 1.85-4.47). Women at low and intermediate risk of relapse accounted for 89% of patients in the study.”The study was underpowered because of difficulties in recruiting patients in a reasonable time so non-inferiority could not be claimed based on the results,” said lead author Pierfranco Conte, Professor of Oncology at the University of Padua and Director of the Division of Medical Oncology at the Instituto Oncologico Veneto, Padua, Italy. He added: “Based on our data, one year trastuzumab remains the standard treatment for women with HER2-positive early breast cancer,”However, Conte added: “Physicians can stop trastuzumab before one year in patients who develop a cardiac event during treatment without compromising efficacy and can consider shorter-duration trastuzumab treatment in patients at risk of cardiac toxicity and a low or intermediate risk of breast cancer relapse.” He suggested that consideration of shorter-duration trastuzumab may also facilitate access to patients who cannot afford a longer course.Commenting on the study for ESMO, Prof. Nadia Harbeck, Head of the Breast Center, University of Munich, said: “The results of this analysis showed that patients with a high tumor load definitely derive substantial benefit from longer duration trastuzumab.”She added: “The results may impact on clinical decision-making, although it is an exploratory analysis of a negative trial so does not meet the criteria to be practice changing. I think it will influence clinicians and patients in that if patients cannot complete one year of trastuzumab, those patients with low tumour burden can feel reassured that they have not lost out on efficacy.”Six-month course of trastuzumab saves nearly £10,000 per patientA second study showed that a six-month course of adjuvant trastuzumab was cost-effective compared to 12 months, giving an average cost saving of nearly £10 000 (Euros 11,300) per patient with no evidence of detriment to quality of life (2).Related StoriesBacteria in the birth canal linked to lower risk of ovarian cancerAI-enabled device detects if targeted chemotherapy is workingNew protein target for deadly ovarian cancerResearchers analyzed the cost-effectiveness of a six-month course of adjuvant trastuzumab compared to the standard 12-month course in patients with HER2 positive early breast cancer taking part in the PERSEPHONE trial. This is the largest phase 3 randomised trial to compare six months with 12 months of trastuzumab and demonstrated non-inferiority of reduced-duration trastuzumab (5).The new study analyzed health service activity and costs in addition to quality of life in 4009 patients who were disease free at six months; 250 were excluded due to lack of data. In a landmark analysis six months into treatment the researchers estimated the cost-effectiveness of six months of trastuzumab compared to a 12-month course of trastuzumab from the perspective of the health and social care sector over two years of follow-up.Results showed the average costs for an individual patient treated with trastuzumab for six months were £2,538.64 (95% confidence interval [CI] £2,383.38-£2,700.72) compared to average costs per patient of £12,333.83 (95% CI £12,098.58-£12,562.27) in those treated with trastuzumab for 12 months.Treating for six months gave an average cost saving of £9,793.25 (95% CI £9,515.86-£10,071.64) per patient. Trastuzumab treatment and administration accounted for the vast majority of this cost saving, with the remainder arising from cardiac assessment and treatment costs and inpatient days.The average Quality Adjusted Life Years (QALYs) for an individual in the 6-month arm and 12-month arm were 1.146 (95% CI: 1.131 – 1.161) and 1.128 (95% CI: 1.113 – 1.144), respectively, giving an average QALY difference of 0.018 (95% CI: – 0.003 – 0.039). Thus the 6-month treatment arm dominated, with a probability of being cost-effective of 100%.”A six-month duration of adjuvant trastuzumab with chemotherapy was found to be cost-effective compared with 12 months, which is currently the standard of care,” said lead author Claire Hulme, Professor of Health Economics at the Academic Unit of Health Economics, University of Leeds, Leeds, UK.She added: “The results, alongside the clinical effectiveness results demonstrating non-inferiority, are the first steps in the safe reduction of treatment for many women with HER-2 positive breast cancer. They present an opportunity for significant cost savings for health service providers.”Hulme acknowledged that a limitation of the study was that it was a landmark study, which meant the researchers looked only at a specific timepoint from six months into trastuzumab treatment. She said the research group intends to carry out further sensitivity analysis and to assess the financial costs of treatment to patients rather than only from the perspective of health service providers.Harbeck commented: “Showing that it was more economical to treat with six months of trastuzumab versus 12 months is an important contribution for global access to treatment.” But she added: “The subgroup analysis of PERSEPHONE could not exclude a benefit of one year trastuzumab in clinically relevant subgroups, so one year remains the standard duration. And we now have biosimilars, which could also help to increase access to treatment in countries where there is no general access.”Looking to the future, she said: “We should not do these trials assuming ‘one size fits all’ for the whole population but we should take into account patients’ individual responses to neoadjuvant anti-HER2 therapy and ask the question whether patients who have sufficient response may forgo further therapy.” She noted that recent research has also shown that high-risk patients benefit from two HER-2 antibodies, such as trastuzumab and pertuzumab, more than one. Source:https://www.esmo.org/center_img Reviewed by James Ives, M.Psych. (Editor)Oct 22 2018Women with HER2-positive early breast cancer with small tumors have similar disease-free survival and lower risk of cardiac toxicity with a nine-week course of adjuvant trastuzumab compared to those treated for one year, according to a subgroup analysis of the Short-HER trial reported at ESMO 2018 Congress in Munich.A second study showed that a six-month course of adjuvant trastuzumab was cost-effective compared to 12 months, with an average cost saving of nearly £10,000 (Euros 11,300) per patient.Current guidelines recommend one year of anti-HER2 antibody therapy as part of standard adjuvant treatment for HER2-positive early breast cancer patients based on the duration of treatment used in pivotal registration trials. There is interest in whether a shorter course of trastuzumab could potentially achieve similar efficacy with lower risk of side-effects and costs.The Short-HER trial randomized 1254 HER2-positive early breast cancer patients to either nine weeks or one year’s treatment with trastuzumab, with both groups also receiving chemotherapy. Results after a median of six years’ follow-up showed the short course did not achieve non-inferiority but was associated with a reduction in the rate of severe cardiac toxicity.The researchers have now analyzed whether there are subgroups of patients where a shorter course of trastuzumab may be non-inferior to a longer course. Multivariate analysis showed that pathologic tumour size (pT) and nodal status (N) were independent prognostic factors for disease-free survival (DFS).They identified three prognostic groups:last_img read more

Scientists make strides in developing liquid biopsies for detecting brain tumor DNA

first_img Source:https://www.cancerresearchuk.org/about-us/cancer-news/press-release/2018-11-06-study-shows-potential-to-develop-brain-tumour-liquid-biopsies Reviewed by James Ives, M.Psych. (Editor)Nov 7 2018Scientists are making strides in developing liquid biopsies for brain tumors by detecting tumor DNA in the fluid from around the brain and spine.Liquid biopsies are fluid samples from patients, for example from the blood or urine, which provide a less invasive way to monitor disease compared to tumor biopsies. A less intrusive test could be hugely beneficial for brain tumors where collecting samples can be difficult and risky for patients.Scientists at the Cancer Research UK Cambridge Institute analyzed cerebrospinal fluid (CSF) – which bathes the brain and spinal cord – in 13 patients with a type of brain tumor called a glioma. They detected tumor DNA in five (39%) of the patients and their findings are published in EMBO Molecular Medicine.Researchers used a cheap and widely available technique called shallow whole-genome sequencing to detect brain tumor DNA – they looked for large genetic changes, such as genes being duplicated or lost.Related StoriesMathematical model helps quantify metastatic cell behaviorStudy provides new insight into longitudinal decline in brain network integrity associated with agingWearing a hearing aid may mitigate dementia riskFor the first time, the researchers identified tumor DNA in the CSF by looking at the size of the DNA fragments, which are shorter than those from healthy cells. This provides another way to detect brain tumor DNA, potentially increasing the detection rate.In one patient, multiple tissue samples from their brain tumor were compared to their CSF. The genetic changes broadly matched, but the CSF contained changes that were missed in some of the tissue samples, suggesting that CSF samples could reflect the repertoire of genetic alterations found in brain tumors.Dr Florent Mouliere, co-first author, who conducted the work as a scientist at the Cancer Research UK Cambridge Institute, said: “Liquid biopsies are showing great promise for a number of cancer types, but tests for brain tumors have lagged behind due to the low levels of tumor DNA found in body fluids, in particular the blood.”Our work shows that a cheap, easily available technique can be used to analyse tumor DNA in cerebrospinal fluid. In the future, we envisage that this technique could be used to identify patients who may benefit from further tests that could help monitor their disease, opening up more tailored treatment approaches.”Around 11,400 people are diagnosed with brain tumors in the UK every year and only 14% of people will survive their disease for a decade or more. That’s why Cancer Research UK has made brain tumor research one of its priorities, spending around £25 million over the next five years.Professor Charles Swanton, Cancer Research UK’s Chief Clinician, said: “Survival for brain tumors remains low and there is an urgent need for research like this to identify strategies to better manage these complex diseases. This study lays important groundwork that brings the possibility of liquid biopsies for this hard to treat disease one step closer.”The researchers will now need to expand this work into larger numbers of patients and find out whether this approach could have applications in the clinic, such as indicating whether a patient’s treatment is working.”last_img read more

Childbirth delivery mode linked with womans risk of developing pelvic floor disorders

first_imgNew study considers a woman’s risk to develop one of four pelvic floor disorders based on childbirth delivery method. Credit: iStock We knew that these disorders are more common after childbirth, but now after following these women for 10 years, we have a good sense of how delivery mode impacts a woman’s risk of developing a pelvic floor disorder.”Victoria Handa, M.D., M.H.S., professor of gynecology and obstetrics at the Johns Hopkins University School of Medicine and director of gynecology and obstetrics at Johns Hopkins Bayview Medical Center Dec 20 2018Decade-long study identifies women at highest risk for incontinenceResearch completed at Johns Hopkins and the Greater Baltimore Medical Center has demonstrated that vaginal childbirth substantially increases the probability a woman will develop a pelvic floor disorder later in life. Pelvic floor disorders, including urinary incontinence and uterine prolapse, afflict millions of women in the United States. However, until now little was known about who will develop these conditions and how they progress over time. In this week’s Journal of the American Medical Association, Johns Hopkins and Greater Baltimore Medical Center researchers report results of a 10-year study showing that some delivery modes, including spontaneous vaginal delivery, are associated with higher risk of some types of pelvic floor disorders. This study considered a woman’s risk of developing one of four pelvic floor disorders: stress urinary incontinence (urine leakage during with activities that increase abdominal pressure), overactive bladder (frequent and urgent urination), anal incontinence (involuntary loss of solid stool, liquid stool or gas) and pelvic organ prolapse (when the uterus and vaginal walls fall downward into the vagina, protruding beyond the vaginal opening when bearing down).The research team enrolled 1,528 women within five to 10 years of their first birth. These women were followed annually for up to nine years. Of the women, 778 delivered all of their children via cesarean birth, 565 had at least one spontaneous vaginal delivery and 185 had at least one delivery involving forceps or vacuum-assistance, also called operative vaginal delivery. The median age at enrollment was 38.3—the youngest study participant at enrollment was 22.7 years old and the oldest participant at the end of the study was age 61.7.Related StoriesLow maternal education linked to high risk of infant mortalityHistory of eating disorders associated with future depressive symptoms among mothersQueen’s researchers develop innovative rapid test to improve maternal health in developing countriesThe team collected information from the women at the time of enrollment, including date of first birth, age at first birth, body mass index, whether they had developed any pelvic floor disorder already, birth delivery mode, and genital hiatus size— the distance between the urethra and the posterior hymen. The team then collected information at follow-up visits—the cesarean birth group made 4,039 visits, the spontaneous vaginal delivery group made 2,817 visits and the operative vaginal delivery group made 948 visits. Some women already had developed pelvic floor disorders at the time of study enrollment while others developed the conditions over the course of the study.In all, the researchers found that cesarean delivery substantially reduced the risk of pelvic floor disorders, most notably pelvic organ prolapse, while operative delivery increased the risk. And for pelvic organ prolapse, the magnitude of these differences grew over time. For example, by 15 years after a first delivery, prolapse of the uterus or vaginal wall beyond the vaginal opening was seen in 9 percent (7–12 percent) of women who had delivered by cesarean, 30 percent (25–35 percent) who had at least one vaginal delivery and 45 percent (37–53 percent) of those who had at least one operative delivery. The researchers also found that a large percentage of new cases of urinary and bowel incontinence developed in the first five years after delivery, while pelvic organ prolapse tended to develop many more years after childbirth. A third discovery was that the genital hiatus size is significantly associated with all pelvic floor disorders but most significantly with pelvic organ prolapse.  This suggests that the genital hiatus size is a marker that might identify women at high risk of developing pelvic floor disorders with aging.center_img While this study was limited to one community hospital and might not accurately reflect populations nation- or world-wide, it is the first time we have been able to gather data over a significant period of time. These data help us understand which women might be at highest risk to develop these conditions. Ultimately this research will help us identify which women should be targeted for prevention strategies, and will hopefully improve our ability to deliver the right type of care to the right person.”Victoria Handa Source:https://www.hopkinsmedicine.org/news/newsroom/news-releases/delivery-method-associated-with-pelvic-floor-disorders-after-childbirthlast_img read more

Sweden shows greatest improvement in saving extremely preterm babies

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 27 2019The survival rate among extremely preterm babies has greatly improved in Sweden, a country that offers top-class neonatal care, a study led from Karolinska Institutet published in the esteemed journal JAMA reports.The researchers have analysed survival among Swedish babies born over 3.5 months prematurely in week 22-26 and compared the statistics from 2014-2016 to those from 2004-2007. All Swedish hospitals participated in the study, which included 2,205 women who had had complications during pregnancy leading to extremely preterm births.Between these two time periods, the stillbirth rate dropped from 30 to 23 per cent, while the survival rate rose from 70 to 77 per cent. Further, the higher survival was not achieved at the cost of more complications during the neonate period; on the contrary, the researchers observed a reduction in the number of brain and lung damage in the babies born between 2014 and 2016, while the number of other problems, such as eye and abdominal complications, remained unchanged.World class survival rate”Even if there are individual hospitals around the world that have been able to show similar results for selected patients, the survival of an entire population and for a whole country is world class,” says Mikael Norman, professor of paediatrics at the Department of Clinical Science, Intervention and Technology at Karolinska Institutet in Sweden and the researcher responsible for the study.By way of comparison, the survival rate for babies born in week 22-26 is around 50 per cent in the UK, France and the USA. And in many comparable countries, it is still rare for babies born in week 22-23 to survive.Greatest improvement in week 22Related StoriesStudy provides new insight into longitudinal decline in brain network integrity associated with agingNeural pathways explain the relationship between imagination and willingness to helpPosterior parietal cortex plays crucial role in making decisions, research showsThe Swedish study found the greatest improvement in survival in babies born in week 22 (from week 22+0 days to week 22+6 days) with birth weights of between 290 and 730 grams. Fifty-eight per cent of those from this group who were admitted to neonatal intensive care between the years 2014 and 2016 survived to at least one year-of-age.The results suggest that central care support initiatives are effective. In recent years, amendments to laws, guidelines and national recommendations have strengthened healthcare provision and the status of extremely preterm babies. Ultimately though, says Professor Norman, the results of the study are testimony to the capabilities of all the midwives, nurses and doctors who provide pregnant women and their babies the best available care 24 hours a day.”The profession and the authorities are both good at taking on board new knowledge and translating it into practice,” he says. “Even if certain problems related to adverse events and long-term complications amongst extremely preterm babies remain as vital areas for improvement, I really think that that Swedish neonatal care should fill us with a sense of pride and joy.”National collaborationLong-standing national collaboration between researchers and clinicians, and the establishment of the national neonatal quality register are other important contributors.”It has been essential to make available knowledge on how neonatal care has developed in Sweden,” says Professor Norman. Source:https://ki.se/en/news/sweden-leads-the-world-in-saving-extremely-preterm-babieslast_img read more

Zuckerberg acknowledges mistakes as Facebook turns 14

Citation: Zuckerberg acknowledges ‘mistakes’ as Facebook turns 14 (2018, February 5) retrieved 18 July 2019 from https://phys.org/news/2018-02-zuckerberg-acknowledges-facebook.html “Over the years, I’ve made almost every mistake you can imagine,” the Facebook co-founder said on his personal page.”I’ve made dozens of technical errors and bad deals. I’ve trusted the wrong people and I’ve put talented people in the wrong roles. I’ve missed important trends and I’ve been slow to others. I’ve launched product after product that failed.”The post, a reflection of the 14 years since Zuckerberg launched Facebook as a Harvard student, was the latest to acknowledge problems in the social network that has grown to some two billion users but has also been criticized for enabling misinformation and manipulation.In recent weeks, Facebook has unveiled steps to refocus on family and friends, even if that means people spend less time on the network.Monday’s post suggested a continual re-evaluation of how Facebook works.”The reason our community exists today is not because we avoided mistakes,” Zuckerberg wrote.”It’s because we believe what we’re doing matters enough to keep trying to solve our greatest challenges—knowing full well that we’ll fail again and again, but that it’s the only way to make progress.” © 2018 AFP Mark Zuckerberg offered fresh self-criticism Monday, acknowledging making numerous mistakes in building the world’s biggest social network as Facebook marked its 14th birthday. Explore further CEO Mark Zuckerberg marked the 14th anniversary of the founding of Facebook with reflections on mistakes he has made in building the biggest social network Facebook to deliver more local news to US users This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more

Backpagecom cofounder released from jail on a 1M bond

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. At a brief hearing at a federal courthouse in Phoenix, James Larkin was ordered by Magistrate Judge John Boyle to put up two properties as surety on the bond.Larkin also was ordered to wear an electronic monitoring device.Larkin, co-founder Michael Lacey and five Backpage.com employees were arrested earlier this month on federal charges.Larkin was the last of the seven to be released from custody. Lacey was released on Friday after posting a $1 million bond.An indictment alleges Backpage.com ignored warnings to stop running advertisements promoting prostitution, sometimes involving children, because the site has brought in $500 million on prostitution-related revenues since its inception in 2004.Authorities say Backpage.com portrays itself as trying to prevent such ads, but investigators have determined the site’s operators have declined to confront the problem. Employees are accused of helping customers edit their ads to say within legal limits while still encouraging commercial sex.The indictment alleges Backpage.com started to launder money earned from ad sales a few years ago after banks raised concerns that they were being used for illegal purposes.Authorities also seized Backpage.com and its affiliated websites as a part of the criminal case.The site founders and four employees have pleaded not guilty in the federal case in Arizona.Authorities revealed last week that Backpage.com CEO Carl Ferrer pleaded guilty to a federal conspiracy charge in Arizona and state money laundering charges in California. In addition, the company pleaded guilty to human trafficking in Texas and in a federal money laundering conspiracy case in Arizona. Ferrer has agreed to testify against others. Citation: Backpage.com co-founder released from jail on a $1M bond (2018, April 17) retrieved 18 July 2019 from https://phys.org/news/2018-04-backpagecom-co-founder-1m-bond.html Explore further © 2018 The Associated Press. All rights reserved. A co-founder of the classified advertising site Backpage.com who has been jailed for the last 10 days on charges of facilitating prostitution was released on a $1 million bond Monday as he awaits trial. Backpage.com, CEO plead guilty to state, US charges read more

Zuckerberg pledges to keep building in noapology address

Facebook CEO Mark Zuckerberg makes the keynote speech at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) “Let’s not do that again soon,” he said. Some analysts said Zuckerberg’s performance bolsters his chances of navigating the company out of its privacy scandal and overcoming concerns that it can’t handle its fake-news and election problems.By leading off with Facebook’s security and privacy responsibilities, then continuing to extend Facebook’s ambitions to connect people in new ways, Zuckerberg successfully “walked the tightrope,” said Geoff Blaber, vice president of research and market analysis firm CCS Insight.”F8 felt like the first time Facebook has been on the front foot since the Cambridge Analytica scandal broke,” Blaber said. Facebook CEO Mark Zuckerberg makes the keynote speech at F8, theFacebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) Facebook CEO Mark Zuckerberg makes the keynote speech at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) Explore further Facebook executives trotted out fun features, most notably a new dating service aimed at building “meaningful, long-term relationships,” in a swipe at sites like Tinder. After Facebook announced its entry into the online dating game, shares of Tinder owner Match Group Inc. plummeted 22 percent.Poking fun at himself, Zuckerberg unveiled a “Watch Party” feature that gives users the ability to watch video together—such as, he suggested, “your friend testifying before Congress.” Up flashed video of Zuckerberg’s own turn on Capitol Hill. Facebook CEO Mark Zuckerberg makes the keynote address at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) Facebook CEO Mark Zuckerberg makes the keynote address at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) With a smile that suggested the hard part of an “intense year” may be behind him, Facebook CEO Mark Zuckerberg addressed developers Tuesday and pledged the company will build its way out of its worst-ever privacy debacle. Facebook CEO Mark Zuckerberg makes the keynote address at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) Facebook CEO Mark Zuckerberg makes the keynote address at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) Facebook CEO Mark Zuckerberg makes the keynote speech at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) Facebook developer conference kicks off amid scandal Zuckerberg then vowed to “keep building,” and reiterated that Facebook is investing a lot in security and in strengthening its systems so they can’t be exploited to meddle with elections, including the U.S. midterms later this year. The company had previously announced almost all of those measures.”The hardest decision I made wasn’t to invest in safety and security,” Zuckerberg said. “The hard part was figuring out how to move forward on everything else we need to do too.”He also unveiled a new feature that gives users the ability to clear their browsing history from the platform, much the same way people can do in web browsers. Then Zuckerberg returned to techno-enthusiasm mode. Facebook CEO Mark Zuckerberg makes the keynote address at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) Facebook CEO Mark Zuckerberg makes the keynote speech at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) © 2018 The Associated Press. All rights reserved. Facebook CEO Mark Zuckerberg makes the keynote address at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) Zuckerberg got big cheers when he announced that the thousands of people in attendance would get Facebook’s latest virtual reality headset—the portable, $199 Oculus Go—for free. “Thank you!” he yelled.Zuckerberg also went out of his way to thank Jan Koum, the co-founder and CEO of messaging platform WhatsApp, who announced his departure Tuesday. Facebook paid $19.3 billion for WhatsApp in 2014.Despite reports that Koum left over concerns about how the company handles private data, Zuckerberg described him warmly as “a tireless advocate for privacy and encryption.” In this April 10, 2018, file photo, Facebook CEO Mark Zuckerberg testifies before a joint hearing of the Commerce and Judiciary Committees on Capitol Hill in Washington about the use of Facebook data to target American voters in the 2016 election. Zuckerberg will kick off F8, the company’s annual conference for software developers, Tuesday, May 1, in San Jose, California, having a fresh opportunity to apologize for Facebook’s privacy scandal and to sketch out Facebook’s future. (AP Photo/Alex Brandon) Facebook CEO Mark Zuckerberg makes the keynote address at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) Dan Goldstein, president of digital marketing agency Page 1 Solutions, said the company “is getting the message” about privacy.”Time will tell, but this may help Facebook overcome the shadow of the Cambridge Analytica scandal,” he said. Facebook CEO Mark Zuckerberg makes the keynote address at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) Facebook CEO Mark Zuckerberg makes the keynote address at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Facebook CEO Mark Zuckerberg makes the keynote speech at F8, the Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) It was a clear and deliberate turning point for a company that’s been hunkered down since mid-March. For first time in several weeks, Zuckerberg went before a public audience and didn’t apologize for the Cambridge Analytica scandal, in which a political data-mining firm accessed data from as many as 87 million Facebook accounts for the purpose of influencing elections. Or for a deluge of fake news and Russian election interference.Instead, Zuckerberg sought to project a “we’re all in this together” mood that was markedly different from his demeanor during 10 hours of congressional testimony just a few weeks ago. His presentation also marked a major change for the company, which seems relieved to be largely done with the damage control that has preoccupied it for the past six weeks.On Tuesday, speaking in San Jose, California, at the F8 gathering of software developers, Zuckerberg said to cheers that the company is re-opening app reviews, the process that gets new and updated apps on its services, which Facebook had shut down in late March as a result of the privacy scandal. Citation: Zuckerberg pledges to ‘keep building’ in no-apology address (2018, May 1) retrieved 18 July 2019 from https://phys.org/news/2018-05-zuckerberg-facebook-conference.html Facebook CEO Mark Zuckerberg makes the keynote address at F8, Facebook’s developer conference, Tuesday, May 1, 2018, in San Jose, Calif. (AP Photo/Marcio Jose Sanchez) read more

Exploring the potential of tall timber buildings

first_imgJustin Brown (left) came to study with Dr Minghao Li (right) after he became aware that much of the latest research on seismic design and timber structures was being generated from UC’s College of Engineering. Credit: Te Rāngai Pūkaha Timber buildings growing in a city near you Citation: Exploring the potential of tall timber buildings (2019, January 31) retrieved 17 July 2019 from https://phys.org/news/2019-01-exploring-potential-tall-timber.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore furthercenter_img Provided by University of Canterbury University of Canterbury (UC) engineering doctoral candidate Justin Brown is guiding future timber core-wall design with his research, paving the way for eco-friendly, mid- to high-rise buildings. “The emergence of engineered wood products has started a renaissance for using timber as a key construction material in mid- to-high-rise buildings,” Brown says.”We’re seeing a lot of hybrid concrete-timber and steel-timber buildings that still rely on concrete or steel cores to resist seismic forces. I’m exploring whether that part of the building could be replaced with a timber solution and to what height this is practicable and economical.”Compared with traditionally built mid- to high-rise buildings, all-timber solutions also have a lower environmental impact. The doctoral student aspires to show that a timber core can be structurally sound and cost competitive, compared with commonly used concrete cores.He is excited about the impact his research will have on future eco-friendly buildings and their seismic resilience.”Aotearoa New Zealand’s earthquake hazard, combined with climate change, is fuelling interest in innovative, sustainable and resilient building solutions,” Brown says.”The timber cores will also adopt low-damage seismic design technologies, so that during major earthquakes, damage to the buildings is minimal and occupancy is restored quickly, meaning minimal repair cost and downtime.”Currently, there are no design tools and minimal research available to help engineers design timber cores. Brown is conducting a large-scale test of cross-laminated timber (CLT) core-walls.”There are already all-timber, multi-storey buildings being built today, but this research would allow for a new type of timber structure to be built. Through large-scale experimental testing of a timber core-wall, engineers will have data and design tools to design multi-storey timber buildings with improved seismic resilience.”last_img read more

Auto reliability up but battery shifting trouble persists

first_imgAutomobiles are getting more reliable, but J.D. Power’s annual survey finds problems with battery failures, transmission shifting and voice recognition systems. © 2019 The Associated Press. All rights reserved. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. In this Feb. 7, 2019, file photo the Lexus LS500 is displayed during the media preview of the Chicago Auto Show in Chicago. J.D. Power’s annual survey found that Lexus was the most dependable brand for the eighth-straight year. (AP photo/Nam Y. Huh, File) Citation: Auto reliability up, but battery, shifting trouble persists (2019, February 13) retrieved 17 July 2019 from https://phys.org/news/2019-02-auto-reliability-battery-shifting-persists.htmlcenter_img Explore further Kia tops new car quality survey for second straight year The survey found that Lexus was the most dependable brand for the eighth-straight year, but some mass-market brands cracked the top five. Porsche and Toyota tied for second, followed by Chevrolet and Buick. The worst performers were Fiat, Land Rover, Volvo, Dodge and a tie between Ram and Acura, the survey said.J.D. Power measures problems per 100 vehicles after three years of ownership. The company collected 32,952 responses from original owners of 2016 model-year vehicles.Owners of all brands reported an average of 136 problems per 100 vehicles this year, six problems fewer than in the 2018 survey.Lexus had 106 problems per 100 vehicles, followed by Porsche and Toyota at 108. Chevrolet had 115 and Buick had 118.Fiat had 249 problems per 100 vehicles, followed by Land Rover at 221, Volvo at 204, Dodge at 178 and Ram and Honda luxury brand Acura tied at 171.The survey found that problems with batteries are on the rise as power seats and sunroofs, larger touch-screens and more computers draw power from them.J.D. Power also found:— Mass market brands outperformed luxury brands in dependability for the first time. The mainstream brands had 136 problems per 100 vehicles, while luxury brands had 141.— The Chrysler brand improved the most, cutting 65 problems off last year’s total to 146.— The Porsche 911 was the most reliable vehicle in the survey this year.last_img read more

Catalonia leader to be tried over separatist propaganda during election

first_img World 14 Apr 2019 Spain’s Sanchez hardens position on Catalonia ahead of election World 23 Apr 2019 Spanish general election candidates clash over Catalonia World 13 Jun 2019 Catalan leaders deny violence, call for dialogue as trial nears end Related News Related News {{category}} {{time}} {{title}} MADRID (Reuters) – The leader of the Spanish region of Catalonia, Quim Torra, will be tried for disobedience after he failed to obey an order to remove separatist propaganda from public offices during election campaigning, the regional court said on Friday. During campaigning for national and local elections in April and May regional leaders were required to remove partisan messages from public offices. But Torra continued to display yellow ribbons – a protest against the jailing of Catalan independence leaders – from government buildings. He could be removed from office for up to two years for failing to comply with the order. The court announced its intention to try him in a tweet.Torra has said he disobeyed because the order was at odds with a resolution adopted by the Catalan parliament and the character of the yellow ribbons was open to subjective interpretation. AdChoices广告Many of the politicians and civil leaders involved in a failed push for secession for the wealthy region two years ago were subsequently arrested, and are now awaiting the decision of the courts, or fled the country and live in self-imposed exile.Spain was plunged into its worst political crisis in decades in 2017 when the then-government of Catalonia called a referendum on secession and then unilaterally declared independence, actions that were both ruled illegal by the constitutional court.The central government invoked a constitutional law to take over the regional authority and called an election, however pro-secessionist parties won a majority and put Torra, a pro-independence activist, in as regional leader. In a letter to the electoral body that made the order, Torra said in March he would not remove the ribbons as he had a duty to respect the right to freedom of expression of public employees. Polls show around half of the electorate in Catalonia supports independence while the other half wishes to stay within Spain. (Reporting by Paul Day; Editing by Frances Kerry)last_img read more