Russian mobile operator Megafon has reportedly beg

first_imgRussian mobile operator Megafon has reportedly begun testing LTE Broadcast technology from Huawei. According to local trade news site ComNews, Megafon is testing LTE Broadcast technology, centred on the eMBMS enhanced multicast standard, in Moscow using capacity in the 2.6GHz range.According to the report, Megafon is testing the broadcast of multiplexed channels rather than individual streams. The company launched an LTE-A network in Moscow earlier this year.Huawei has been developing LTE Broadcast technology for some time. It tested the technology with Philippines operator Smart Communications using 2.1GHz spectrum last year and has also been previously linked with the BBC’s plans for LTE services.Late last year Huawei teamed up with chipmaker Sequans Communications to conduct interoperability tests of Huawei’s LTE equipment and end user devices based on Sequans’ eMBMS-capable chips.last_img read more

Viacom is to migrate its German MTV HD channel to

first_imgViacom is to migrate its German MTV HD channel to the SES-backed HD satellite platform HD+ from the beginning of September.MTV HD will henceforth be a free-to-air service on satellite, with HD+ users paying an annual technical fee to receive the raft of services on the platform. HD+ had around 1.4 million paying customers and a further 1.3 million on free trials at the end of last year.Viacom’s northern Europe chief Magnus Kastner had previously indicated that MTV would become an HD-only brand.last_img read more

Reported by WVUA 23 Reporter Erin McNally Construc

first_imgReported by WVUA 23 Reporter Erin McNallyConstruction crews have started on a new Alabama Highway 69 South project.The Alabama Department of Transportation has begun to add a through lane from south of the I-59/20 ramp to the south of the Highway 69 South and Skyland Boulevard intersection.“Well we’re trying to add another lane to tie into the third lane that’s going up to 69 south,” said David Walker, a transportation maintenance technician III with ALDOT.The project should wrap up in about two weeks, but that can change depending on the weather. Officials said the project is necessary due to the growing driver population in Tuscaloosa.“The city continues to grow and we try to grow with it,” Alabama Department of Transportation Public Information Officer John McWilliams said. “The city has grown by 10.9 percent since 2010 and it’s the fastest growing major five city in Alabama, so this is our way to keep up with that growth.”Roadwork will be taking place between 9 a.m. to 3 p.m. to better accommodate traffic. In addition, crews will be performing maintenance to roads in various areas throughout the work zone.“It’s good to see improvements,” Tuscaloosa driver Charles Lavender said. “It’s way past due, way past due. A lot of things could be better, but that’s good. They’re making progress.”During the 10 day period of construction, motorists can expect intermittent lane closures within the project limits and possible delays. All drivers should use extreme caution in work zones.last_img read more

USA Today published an opinion column by President

first_imgUSA Today published an opinion column by President Trump Wednesday in which the president falsely accused Democrats of trying to “eviscerate” Medicare, while defending his own record of protecting health care coverage for seniors and others.The column — published just weeks ahead of the midterm elections — underscores the political power of health care to energize voters. But it makes a number of unsubstantiated claims.Here are 5 points to know1. The political context: Health care has emerged as a dominant issue on the campaign trail in the runup to the November elections. According to the Wesleyan Media Project, which tracks congressional advertising, health care was the focus of 41 percent of all campaign ads in September, outpacing taxes (20 percent), jobs (13 percent) and immigration (9 percent). Democrats are particularly focused on health care, devoting 50 percent of their ads to the issue, but health care is also a leading issue in Republican commercials (28 percent), second only to taxes (32 percent).Perhaps sensing that Democrats are gaining traction, Trump has decided to go on the attack, targeting the Democratic proposal known as “Medicare for All.”2. Cost of the plan: Trump claims that expanding the federal government’s Medicare program would cost $32.6 trillion over a decade. But as Business Insider reports, that would actually be a discount compared with the nation’s current health care bill.Trump’s figure was calculated by the libertarian Mercatus Center, but he fails to note that total health care spending under Medicare for All would be about $2 trillion less over the decade than currently projected. The federal government would pay more, but Americans on the whole would pay less.Remember that the U.S. already spends far more per person on health care than does any other country. And when you count the tax break for employer-provided insurance, the federal government already pays about two-thirds of this bill. But because of the fragmented private insurance system, the government gets none of the efficiency or buying power that a single-payer system would provide.3. Health care rationing: Trump claims — with no supporting evidence — that “the Democratic plan would inevitably lead to the massive rationing of health care. Doctors and hospitals would be put out of business. Seniors would lose access to their favorite doctors. There would be long wait lines for appointments and procedures. Previously covered care would effectively be denied.”Detailed implementation of any single-payer plan would of course be subject to substantial negotiation. But the Medicare for All bill drafted by Sen. Bernie Sanders, I-Vt., states explicitly that “Nothing in this Act shall prohibit an institutional or individual provider from entering into a private contract with an enrolled individual for any item or service” outside the plan.4. Pre-existing conditions: Trump notes that as a candidate, he “promised that we would protect coverage for patients with pre-existing conditions.” In fact, Trump and his fellow Republicans tried — unsuccessfully — to repeal the Affordable Care Act, which guarantees insurance coverage for people with pre-existing conditions. GOP plans would leave it up to the states to craft alternative protections. In addition, Republican attorneys general have sued to overturn Obamacare’s protections, and the Trump administration has declined to defend them.America’s Health Insurance Plans, the trade group for the insurance industry, warns that ending the Obamacare guarantee could result in hardship for the estimated 130 million Americans under 65 with pre-existing conditions.”Removing those provisions will result in renewed uncertainty in the individual market, create a patchwork of requirements in the states, cause rates to go even higher for older Americans and sicker patients, and make it challenging to introduce products and rates for 2019,” AHIP said in a statement in June.5. Strength of Medicare: Trump writes that “Democrats have already harmed seniors by slashing Medicare by more than $800 billion over 10 years to pay for Obamacare. Likewise, Democrats would gut Medicare with their planned government takeover of American health care.”He is repeating a claim that was widely debunked during the 2012 election. The Affordable Care Act actually strengthened the solvency of Medicare, but it has since been weakened again by the GOP tax cut.The president is trying to play on the fears of seniors — who vote in large numbers — with the claim that any effort to improve health security for younger Americans must come at their expense. But that is a false choice. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

The American Medical Association is suing North Da

first_imgThe American Medical Association is suing North Dakota to block two abortion-related laws, the latest signal the doctors’ group is shifting to a more aggressive stance as the Trump administration and state conservatives ratchet up efforts to eliminate legal abortion.The group, which represents all types of physicians, has tended to stay on the sidelines of many controversial political issues, and until recently has done so concerning abortion and contraception. Instead, it has focused on legislation that affects the practice and finances of large swaths of its membership.But, said AMA President Patrice Harris in an interview, the organization felt it had to take a stand because new laws forced the small number of doctors who perform abortions to lie to patients, putting “physicians in a place where we are required by law to commit an ethical violation.”One of the laws, set to take effect Aug. 1, requires physicians to tell patients that medication abortions — a procedure involving two drugs taken at different times — can be reversed. The AMA said that is “a patently false and unproven claim unsupported by scientific evidence.” North Dakota is one of several states to pass such a measure, even as researchers who study the procedure say it’s not effective.The AMA, along with the last remaining abortion clinic in the state, is also challenging an existing North Dakota law that requires doctors to tell pregnant women that an abortion terminates “the life of a whole, separate, unique, living human being.” The AMA said that law “unconstitutionally forces physicians to act as the mouthpiece of the state.”It’s the second time this year the AMA has taken legal action on an abortion-related issue. In March, the group filed a lawsuit in Oregon in response to the Trump administration’s new rules for the federal family planning program. Those rules would, among other things, ban doctors and other health professionals from referring pregnant patients for abortions.”The Administration is putting physicians in an untenable situation, prohibiting us from having open, frank conversations with our patients about all their health care options — a violation of patients’ rights under the [AMA] Code of Medical Ethics,” wrote then-AMA President Barbara McAneny.It’s an unusually assertive stance for a group that has taken multiple positions on abortion-related issues over the years.Mary Ziegler, a law professor at Florida State University who has written several books about abortion, says that the AMA’s history on abortion is complicated. In general, she says, the AMA “didn’t want to get into the [abortion] issue because of the political fallout and because historically there have been doctors in the AMA on both sides of the issue.”In recent years, the AMA has taken mostly a back seat on abortion issues, even ones that directly addressed physician autonomy, leaving the policy lead to specialty groups like the American College of Obstetricians and Gynecologists, which has consistently defended doctors’ rights to practice medicine as they see fit when it comes to abortion issues.Ziegler says it is not entirely clear why the AMA has suddenly become more outspoken on women’s reproductive issues. One reason could be that the organization’s membership is skewing younger and less conservative. Also, this year, for the first time, the AMA’s top elected officials are all women.In its earliest days, the AMA led the fight to outlaw abortion in the late 1800s, as doctors wanted to assert their professionalism and clear the field of “untrained” practitioners like midwives.Abortion was not an issue for the group in the first half of the 20th century. The AMA became best-known for successful fights to fend off a national health insurance system.Leading up to Roe v. Wade, the 1973 Supreme Court decision that legalized abortion nationwide, the AMA softened its opposition. In 1970, the AMA board called for abortion decisions to be between “a woman and her doctor.” But the organization declined to submit a friend-of-the-court brief to the high court during its consideration of Roe.In 1997, the AMA, in a surprise move, endorsed a GOP-backed measure to ban what opponents called “partial-birth abortions,” a little used procedure that anti-abortion forces likened to infanticide. A year later, however, an audit of the AMA’s leadership found its trustees had “blundered” in endorsing the bill and had contradicted long-standing AMA policy.One reason the organization may be moving on the issue now could be the shifting parameters of the abortion debate itself. In 1997, the abortion procedure ban that the AMA endorsed “polled well and allowed abortion opponents to paint the other side as extremist,” Ziegler says.Exactly the opposite is true today, she says, as states pass abortion bans more sweeping than those seen at any time since Roe. Yet most public opinion polls show a majority of Americans want abortion to remain legal in many or most cases.”As abortion opponents take more extreme positions, the AMA is probably a little more comfortable intervening” Ziegler adds.Molly Duane, a lawyer from the Center for Reproductive Rights who is arguing the case for the AMA and North Dakota’s sole remaining abortion clinic, says the laws being challenged are “something all doctors should be alarmed by. … This is an unprecedented act of invading the physician-patient relationship and forcing words into the mouths of physicians.”Kaiser Health News is a national health policy news service. It is an editorially independent program of the Henry J. Kaiser Family Foundation, which is not affiliated with Kaiser Permanente. Copyright 2019 Kaiser Health News. To see more, visit Kaiser Health News.last_img read more

Tesla Misses Delivery Target Again Following Rough Month Start Up Your Day

first_img Learn how to successfully navigate family business dynamics and build businesses that excel. Free Webinar | July 31: Secrets to Running a Successful Family Business Contributor Grace Reader Add to Queue –shares Start Up Your Day Tesla Misses Delivery Target Again Following Rough Month — Start Up Your Day Roundup Looking for the latest headlines in small business, innovation and tech? Our Start Up Your Day recaps are posted every morning to keep you current.Under fire. Tesla is having a rough month — the company missed its delivery target for the third consecutive quarter.Technology for good. Apple is encouraging organ donation by making it easy for users of the upcoming iOS 10 software to add themselves to the national registry list.That’s the stuff. Hostess Brands is getting a new owner and going public.Sneak peek. Microsoft is adding a wheelchair avatar option for Xbox, along with other visual updates.A new way to pay. Walmart Pay, intended to make the checkout process faster with QR codes, is now active in 14 states.Spacing out. NASA’s Juno space probe successfully started orbiting Jupiter. Put on this music to celebrate.More money. The Mega Millions jackpot is now $449 million, the seventh-largest prize in U.S. history.center_img July 5, 2016 Image credit: Jim Dyson / Contributor | Getty Images Register Now » Opinions expressed by Entrepreneur contributors are their own. Guest Writer 1 min read Next Article last_img read more

Insite Software Announces Major New Enhancements for InsiteCommerce

first_imgInsite Software Announces Major New Enhancements for InsiteCommerce PRNewswireJune 21, 2019, 6:48 pmJune 21, 2019 B2B CommerceBrand EnhancementsEmail List ReminderInsite SoftwareInsiteCommerce 4.5.0Marketing TechnologyNews Previous ArticleTencent Champions “Tech for Good” in CannesNext ArticleLeading Associations Turn to ON24 for Member Engagement and Revenue Growth Leader in B2B Commerce Software Releases Insitecommerce 4.5.0 With Additional Functionality for Email, List Share, Search, Security and MoreInsite Software, a leading provider of powerful digital commerce solutions architected for manufacturers and distributors, announced it has launched InsiteCommerce 4.5.0, the latest version of Insite’s industry-first eCommerce platform. InsiteCommerce 4.5.0 includes several major new updates based on both customer feedback and Insite B2B commerce innovation. In addition to improving Insite’s already powerful search capabilities, version 4.5.0 provides new functionality that enables email list reminders, provides multiple customer list share features, enhances security for commerce sites and delivers integration with inRiver cloud products.“Insite has stayed in front of the B2B commerce industry by prioritizing new features and functionality based on customer feedback combined with the deep expertise of Insite’s development team,” said Steve Shaffer, Chief Executive Officer of Insite Software. “We’re dedicated to listening to our customers’ needs and wants and responding with continuous improvement of our eCommerce solutions. InsiteCommerce 4.5.0 is a reflection of that powerful approach.”Marketing Technology News: Cerebri AI named a 2019 Cool Vendor in Artificial Intelligence for Customer Analytics by GartnerInsiteCommerce 4.5.0 includes new features within six major areas of the solution including:Email List Reminder functionality allows customers to set email reminders to reorder items on a recurring basis and at regular intervals from a specific list. Insite’s robust list management capabilities already increase efficiencies for buyers and sellers. This new functionality is designed to boost productivity even further with daily jobs that generate emails based on the schedule defined by a storefront user.With List Share for Multiple Customers, Insite’s list functionality has been enhanced to serve the needs of customers who share lists with large groups of customers. The tool now allows users to create, manage and share lists with multiple customers from the Admin Console. This provides manufacturers and distributors with the capability to promote specific products, highlight recommended or approved products, or streamline access to their most in demand products.InsiteCommerce 4.5.0 provides Search Enhancements that make search results even more relevant to their customers.  There are additional options that enable business users to configure search logic to better match customers’ expectations. Users have more control to improve multi-word and phrase search logic, improve part number matching when part numbers have special characters or include manufacturer part numbers, and prevent ‘did you mean’ logic from being applied to part numbers.Marketing Technology News: Elixirr and Usermind Partner to Help Brands Get More Value from Customer Experience InitiativesThe Insite platform now provides new security capability in terms of Bad Actor Prevention, giving customers the ability to decide who can be on their site while preventing visitors from scraping information from the site for other purposes.Shop by Brand Enhancements allow users to configure search, boost and bury by brands and product lines, offers a new brand gallery widget, improves SEO for brand pages and provides stronger ability to highlight specific brands. This update gives distribution customers the ability to easily raise the visibility of certain brands, a desirable feature for promotion and partnership purposes.InsiteCommerce 4.5.0 now seamlessly talks to inRiver cloud implementations with its updated inRiver Connector. This connector allows all product, item, resource and channel information to be synchronized directly from inRiver to the InsiteCommerce platform. Insite’s integration with inRiver leverages the rich data that a PIM can provide and allows manufacturers and distributors to seamlessly update product content with the flexibility to deploy inRiver either on premise or in the cloud.Marketing Technology News: Publicis Sapient Announces John Maeda as Chief Experience Officerlast_img read more

HOOQ Streams Live and OnDemand Video Content on Brightcove Video Platform

first_imgHOOQ Streams Live and On-Demand Video Content on Brightcove Video Platform PRNewswireJune 24, 2019, 8:17 pmJune 24, 2019 brightcoveBrightcove SSAIBrightcove video platformHOOQMarketing TechnologyNews Previous ArticleRazer and Visa Announce Partnership to Transform Payments in Southeast AsiaNext ArticleRising Focus by Businesses to Increase Customer Satisfaction and Optimize Supply Chain Will Significantly Propel the Growth of Enterprise Software Market: IndustryARC Brightcove, the leading provider of cloud services for video, announced that HOOQ, Asia’s leading OTT service, has selected the Brightcove Video Platform as the underlying streaming solution to power its live and video-on-demand service to subscribers across Singapore, Indonesia, Thailand, Philippines, and India, serving a market size of over one billion consumers.Launched in 2015 in partnership with Sony Pictures, Warners Bros, and Singtel, HOOQ is a premium subscription-based OTT video service. Since its launch, the company has added over 20 channels to its offering in partnership with some of the biggest brands in the industry, such as Discovery Channel, TLC, Hits, as well as local and regional channels.The underlying streaming technology of the HOOQ platform is powered by Brightcove video platform technology, allowing the company to seamlessly stream live and on-demand content at scale, on any device, and monetise content using a combination of payment tiers including: ad-supported, subscription and transactional-video on demand, as well as a freemium layer with over 20 free-to-air (FTA) channels. HOOQ also serves ads on its live streamed content with server-side ad insertion technology powered by Brightcove SSAI. With SSAI technology, HOOQ seamlessly integrates ads into the video stream, delivering a premium viewing experience without buffering or disruptions.Marketing Technology News: GoSpotCheck Gains Valuable Leadership Expertise with Five Additions to Management Team“HOOQ serves multiple countries with large population sizes, so our streaming technology must be uncompromisingly robust, reliable, highly scalable, and easy to integrate into our proprietary architecture,” said Michael Fleishman, Chief Technology Officer of HOOQ. “Brightcove met all of our criteria and provided us the flexibility to quickly roll out new service features, including the ability to seamlessly stitch ads into our live streams. Brightcove’s in-region presence, deep understanding of the media industry in Southeast Asia, and the ability to tap into support resources was also a key factor in our decision to partner with them.”Marketing Technology News: Medallia Names Software Industry Veteran Rob Bernshteyn to its Board of Directors“HOOQ is a regional powerhouse vying to capture a sizeable portion of the Asian consumer market,” said Sara Larsen, Chief Marketing Officer, Brightcove. “We are proud to power HOOQ’s service and support the company’s mission to tell one million stories to one billion people. We have worked diligently with HOOQ to deliver a platform that satisfies the demands of consumers who want access to content on any device, at any time, with an exceptional viewer experience.”HOOQ delivers over 10,000 hours of Hollywood blockbusters and television series as well as popular local movies and programs, plus over 50 live channels to customers.Marketing Technology News: LiveVox and TDECU Share Keys to Optimizing the Customer Experience in a Digital Environment at CCW 2019last_img read more

Scientists make strides in developing liquid biopsies for detecting brain tumor DNA

first_img Source:https://www.cancerresearchuk.org/about-us/cancer-news/press-release/2018-11-06-study-shows-potential-to-develop-brain-tumour-liquid-biopsies Reviewed by James Ives, M.Psych. (Editor)Nov 7 2018Scientists are making strides in developing liquid biopsies for brain tumors by detecting tumor DNA in the fluid from around the brain and spine.Liquid biopsies are fluid samples from patients, for example from the blood or urine, which provide a less invasive way to monitor disease compared to tumor biopsies. A less intrusive test could be hugely beneficial for brain tumors where collecting samples can be difficult and risky for patients.Scientists at the Cancer Research UK Cambridge Institute analyzed cerebrospinal fluid (CSF) – which bathes the brain and spinal cord – in 13 patients with a type of brain tumor called a glioma. They detected tumor DNA in five (39%) of the patients and their findings are published in EMBO Molecular Medicine.Researchers used a cheap and widely available technique called shallow whole-genome sequencing to detect brain tumor DNA – they looked for large genetic changes, such as genes being duplicated or lost.Related StoriesMathematical model helps quantify metastatic cell behaviorStudy provides new insight into longitudinal decline in brain network integrity associated with agingWearing a hearing aid may mitigate dementia riskFor the first time, the researchers identified tumor DNA in the CSF by looking at the size of the DNA fragments, which are shorter than those from healthy cells. This provides another way to detect brain tumor DNA, potentially increasing the detection rate.In one patient, multiple tissue samples from their brain tumor were compared to their CSF. The genetic changes broadly matched, but the CSF contained changes that were missed in some of the tissue samples, suggesting that CSF samples could reflect the repertoire of genetic alterations found in brain tumors.Dr Florent Mouliere, co-first author, who conducted the work as a scientist at the Cancer Research UK Cambridge Institute, said: “Liquid biopsies are showing great promise for a number of cancer types, but tests for brain tumors have lagged behind due to the low levels of tumor DNA found in body fluids, in particular the blood.”Our work shows that a cheap, easily available technique can be used to analyse tumor DNA in cerebrospinal fluid. In the future, we envisage that this technique could be used to identify patients who may benefit from further tests that could help monitor their disease, opening up more tailored treatment approaches.”Around 11,400 people are diagnosed with brain tumors in the UK every year and only 14% of people will survive their disease for a decade or more. That’s why Cancer Research UK has made brain tumor research one of its priorities, spending around £25 million over the next five years.Professor Charles Swanton, Cancer Research UK’s Chief Clinician, said: “Survival for brain tumors remains low and there is an urgent need for research like this to identify strategies to better manage these complex diseases. This study lays important groundwork that brings the possibility of liquid biopsies for this hard to treat disease one step closer.”The researchers will now need to expand this work into larger numbers of patients and find out whether this approach could have applications in the clinic, such as indicating whether a patient’s treatment is working.”last_img read more

Researchers identify potential target for new breast cancer treatments

Source:https://www.kcl.ac.uk/lsm/schools/basic-and-medical-biosciences/newsrecords/2018/dec/fight-against-breast-cancer-new-target-identified.aspx Reviewed by James Ives, M.Psych. (Editor)Dec 18 2018Researchers from the School of Basic & Medical Biosciences have identified a potential target that could lead to new treatments for triple negative breast cancer.One in five patients with breast cancer are diagnosed with triple negative breast cancer, a cancer type where tumour cells don’t have receptors for oestrogen and progesterone, or the Her2 protein. Because of this, hormone treatments and the targeted drug Herceptin don’t work in patients with this type of cancer.To improve outcomes for women with this form of cancer, research that could increase the available treatment options is vital.In a paper published in Clinical Cancer Research, King’s researchers have identified a potential avenue for developing new treatments. They found that many triple negative breast cancer tumours have a molecule on their surface called folate receptor alpha, and that antibodies for the receptor can be targeted directly to these cancer cells.Related StoriesSpecial blood test may predict relapse risk for breast cancer patientsStudy reveals link between inflammatory diet and colorectal cancer riskCancer killing capability of lesser-known immune cells identifiedThe research suggests that antibody immunotherapies could be effective, as these prime the immune system to recognise and attack cancer cells. Possible new treatments could also link antibodies for the receptor molecule to drugs that attack cancer cells and target the treatment directly to tumours.The researchers used a range of methods to understand how the antibodies might be targeted. They looked at Folate Receptor alpha expression in samples from over three thousand triple negative breast cancer tumours. They also looked at the effects of antibodies on folate receptor alpha in cells in a dish, and in tumour xenografts.Dr Sophia Karagiannis, Reader in Translational Cancer Immunology at St John’s Institute of Dermatology said: At the moment, the research shows that Folate Receptor alpha might be a potential target for new treatments, but it will take time to develop effective treatments, and to run the clinical trials required to make sure the treatments are safe and effective.Professor Andrew Tutt, Director of the Breast Cancer Now Research Unit at King’s College London said: “Having identified antibodies against this novel target that are able to restrict the growth of Triple Negative Breast Cancer cells in the laboratory, we are now concentrating on bringing forth a new generation of more effective antibody therapy approaches. Our ultimate aim is to translate the most promising of these to clinical testing in patients.” “Through our combined strengths in breast cancer biology, cancer immunology, antibody engineering, and translation of targeted therapies at the Breast Cancer Now Unit at King’s, we are able to venture beyond existing conventional treatments, identify new targets on cancer cells and develop new agents for therapy never before examined in breast cancer.””But it’s important to remember that this research is at an early stage, and further work is needed in the laboratory before we know if these could develop into treatments for patients.” read more

Sweden shows greatest improvement in saving extremely preterm babies

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 27 2019The survival rate among extremely preterm babies has greatly improved in Sweden, a country that offers top-class neonatal care, a study led from Karolinska Institutet published in the esteemed journal JAMA reports.The researchers have analysed survival among Swedish babies born over 3.5 months prematurely in week 22-26 and compared the statistics from 2014-2016 to those from 2004-2007. All Swedish hospitals participated in the study, which included 2,205 women who had had complications during pregnancy leading to extremely preterm births.Between these two time periods, the stillbirth rate dropped from 30 to 23 per cent, while the survival rate rose from 70 to 77 per cent. Further, the higher survival was not achieved at the cost of more complications during the neonate period; on the contrary, the researchers observed a reduction in the number of brain and lung damage in the babies born between 2014 and 2016, while the number of other problems, such as eye and abdominal complications, remained unchanged.World class survival rate”Even if there are individual hospitals around the world that have been able to show similar results for selected patients, the survival of an entire population and for a whole country is world class,” says Mikael Norman, professor of paediatrics at the Department of Clinical Science, Intervention and Technology at Karolinska Institutet in Sweden and the researcher responsible for the study.By way of comparison, the survival rate for babies born in week 22-26 is around 50 per cent in the UK, France and the USA. And in many comparable countries, it is still rare for babies born in week 22-23 to survive.Greatest improvement in week 22Related StoriesStudy provides new insight into longitudinal decline in brain network integrity associated with agingNeural pathways explain the relationship between imagination and willingness to helpPosterior parietal cortex plays crucial role in making decisions, research showsThe Swedish study found the greatest improvement in survival in babies born in week 22 (from week 22+0 days to week 22+6 days) with birth weights of between 290 and 730 grams. Fifty-eight per cent of those from this group who were admitted to neonatal intensive care between the years 2014 and 2016 survived to at least one year-of-age.The results suggest that central care support initiatives are effective. In recent years, amendments to laws, guidelines and national recommendations have strengthened healthcare provision and the status of extremely preterm babies. Ultimately though, says Professor Norman, the results of the study are testimony to the capabilities of all the midwives, nurses and doctors who provide pregnant women and their babies the best available care 24 hours a day.”The profession and the authorities are both good at taking on board new knowledge and translating it into practice,” he says. “Even if certain problems related to adverse events and long-term complications amongst extremely preterm babies remain as vital areas for improvement, I really think that that Swedish neonatal care should fill us with a sense of pride and joy.”National collaborationLong-standing national collaboration between researchers and clinicians, and the establishment of the national neonatal quality register are other important contributors.”It has been essential to make available knowledge on how neonatal care has developed in Sweden,” says Professor Norman. Source:https://ki.se/en/news/sweden-leads-the-world-in-saving-extremely-preterm-babieslast_img read more

Innovative singlechip platform speeds up drug development process

first_imgBy Dr. Liji Thomas, MDJul 16 2019Scientists at the Karlsruhe Institute of Technology (KIT) have come up with a miniaturized and accelerated system of new drug development on just one chip, promising to make the process faster and cheaper than ever before. The report was published in the journal Nature Communications on June 28, 2019.The demand for newer drugs is constantly rising with the emergence of novel and drug resistant diseases. However, fewer new drugs are actually being developed (about 600 over the period 1991-2010 in the top countries). One big reason is the sheer complexity and expense of the many steps involved, which are typically performed one after the other, in separate processes. However, this may no longer be the case, say the KIT scientists who developed a new combinatorial on-chip process. The traditional process of drug development is a slow and tedious one. It begins with searching compound databases for new active chemicals, producing them individually in adequate quantities using high-throughput systems to build a compound library, characterizing them, and cell-based screening to make sure they possess activity in biological systems. Compounds with promising activity are called hits and are returned for further exploration. The process is repeated for different variations of the hits to form a secondary library of molecules with molecules optimized for the intended application.Several runs are required before the final candidates are established, and these enter the medical phase of development for testing in clinical studies. Only one among the thousands of molecules screened initially reaches this stage. Sometimes none of the hits makes it through drug approval. The flaws in this workflow are obvious: it is slow, cumbersome, consumes much reagent and solvents, costs a huge amount and limits the number of initial compounds screened within the limits of feasibility. At present, drug development cycles often span two or more decades at a cost of 2 to 4 billion dollars, making them huge, slow and extremely costly beasts.An advance in this field is the use of solid-phase synthesis in microarray format to miniaturize and combine the synthesis of multiple compounds. However, it does not allow cell-based assays for bioactivity in most cases. Until now, there were no miniaturized processes to run high-throughput production workflows for liquid phase chemicals. Secondly, compounds with biological activity cannot be produced and screened simultaneously using the same process.Related StoriesRaman Spectroscopy as a Universal Analytical Technique for Bodily FluidsNanoparticles used to deliver CRISPR gene editing tools into the cellNanotechnology-based compound used to deliver hepatitis B vaccineThe new on-chip combinatorial platform chemBIOS could change all that. KIT scientist Maximilian Benz says, “We have developed a platform that combines synthesis of compound libraries with biological high-throughput screening on a single chip.”The chemBIOS platform can thus deal with all three components of the drug development process at once: synthesize a database of fats in a microarray format using organic solvents, use mass spectroscopy techniques to characterize all of them in a single step, and then test them for bioactivity using aqueous solutions. Following synthesis, the fats form lipoplexes, or lipid-nucleic acid complexes, which can be taken up for use by both animal and human cells for bioassays. The chemBIOS chip allows single-step transfer of the whole library from the organic solvent platform (for synthesis and characterization) to the aqueous solution platform (for high-throughput bioassay) by sandwiching them.  In this way, says Benz, the chip is used to “perform 75 parallel three-component reactions for synthesis of a library of lipids, i.e. fats, followed by characterization using mass spectroscopy, on-chip formation of lipoplexes, and biological cell screening.”The advantages are enormous. It cuts down on the time required and uses only miniscule amounts of all the solutions, as against the usual requirement of several liters of reactant, solvent fluids, and cell suspensions. It allows multiple screenings of the same library to enhance the identification of hits.The chemBIOS is a front-runner for the 2019 NEULAND Innovation Prize awarded by KIT). It seems that this prize-winning technology could lead to incredibly fast and inexpensive drug development if its potential is borne out in future tests. More work is needed for reactions involving high temperatures, gaseous byproducts, solid reagents, or those which need a strictly controlled environment. High-throughput purification is another avenue that needs to be explored, but the flat surface of the chemBIOS chip would apparently favor such methods.Benz puts it all together: “The entire process from library synthesis to cell screening takes only three days and about 1 ml of total solution, demonstrating the potential of the chemBIOS technology to increase efficiency and accelerate screenings and drug development.” Journal reference:Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening, Maximilian Benz, Mijanur R. Molla, Alexander Böser, Alisa Rosenfeld & Pavel A. Levkin, Nature Communicationsvolume 10, Article number: 2879 (2019), 10.1038/s41467-019-10685-0ID, https://www.nature.com/articles/s41467-019-10685-0 Array of microdroplets with various reactants on the chemBIOS chip-based synthesis platform. Image Credit: Maximilian Benz, KITlast_img read more

Amazons Bezos finalizes divorce with 38 bn settlement report

first_img © 2019 AFP Amazon CEO Jeff Bezos and wife MacKenzie Bezos, pictured here in February 2017, finalized their divorce at $38 billion This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Amazon’s Bezos, wife reach biggest divorce deal in history (Update) Citation: Amazon’s Bezos finalizes divorce with $38 bn settlement: report (2019, July 6) retrieved 17 July 2019 from https://phys.org/news/2019-07-amazon-bezos-divorce-bn-settlement.htmlcenter_img Under the agreement, MacKenzie Bezos, 49, will receive approximately 19.7 million Amazon.com shares, giving her a four percent stake in the company valued at $38.3 billion, and landing her at 22nd on the Bloomberg Billionaires Index, the news service said.A judge in Washington state’s King County finalized the divorce. Jeff Bezos, 55, will retain a 12 percent stake and remain the world’s richest man.MacKenzie Bezos, a novelist, has said she would give all of her stake in The Washington Post and the space exploration firm Blue Origin to her husband as well as voting control of her remaining Amazon stock.She has also promised to donate half her fortune to charity, joining the ranks of the world’s ultra-wealthy philanthropists as a signatory of the Giving Pledge.The personal life of Jeff Bezos was thrust into the spotlight with the announcement in January that he and his wife were divorcing after 25 years of marriage and the revelation by the National Enquirer that he had been having an affair with a former news anchor, Lauren Sanchez.Jeff and MacKenzie Bezos married in 1993 and have four children. Jeff Bezos founded Amazon in their Seattle garage in 1994 and turned it into a colossus that dominates online retail. Explore further Amazon founder Jeff Bezos and MacKenzie Bezos finalized their divorce Friday to the tune of a $38-billion settlement, Bloomberg News reported.last_img read more

JK 2 militants killed security personnel injured in encounter in ShopianJK 2

first_img COMMENT SHARE SHARE EMAIL July 10, 2018 terrorism (crime) Published on armycenter_img SHARE Jammu and Kashmir Two militants were killed and a security personnel was injured today in an encounter in Jammu and Kashmir’s Shopian district, police said. Three civilians were also hurt after protestors clashed with security forces near the site of the gunbattle in Kundullan village, they said. Bodies of two militants were recovered from the site at Kundullan in the district, a police spokesman said. Security forces launched a cordon and search operation in the village early this morning following information about the presence of militants there, a police official said. He said the search operation turned into an encounter after the militants opened fire on the security forces, who retaliated. The official said a jawan was injured in the exchange of fire with the militants. He said a large number of civilians rushed towards the encounter site at Kundullan and started pelting stones at security personnel. “The three civilians were injured in action by security forces to chase away the protestors,” he said. COMMENTSlast_img read more

England could bring World Cup high into Ashes says Ponting

first_img(Reuters) – Former Australia captain Ricky Ponting believes England’s success in their home World Cup may bode ill for Australia’s hopes of retaining the Ashes.England knocked Australia out of the semi-finals with an emphatic eight-wicket win and another over New Zealand in Sunday’s final will see the hosts head into next month’s five-test Ashes series with significant momentum.”It probably does, to be honest,” Ponting said, when asked whether England’s 50-over success could spill over.”The country will be on a bit of a wave and a bit of a high, the players will certainly be on a huge high after that World Cup. Cricket 07 Jul 2019 England quick Anderson suffers calf injury ahead of Ashes Related News Cricket 25 Jun 2019 Australia can draw inspiration from World Cup pedigree – Finch “But who knows if they don’t (win), it might have an adverse effect on their Ashes campaign as well.”You can take lots of things from different series.”It’s a completely different series going into an Ashes and there will be quite a few different players in their Test team than will be in this one-day team. They’ll have different captains as well.”But I’m sure if they happen to win the World Cup, they’ll take as much as they can from it going into the Ashes.”Australia hold the urn after thrashing England 4-0 on home soil in the 2017-18 Ashes.The first Ashes test starts at Edgbaston on Aug. 1.Ponting, hired as an assistant coach to Justin Langer for Australia’s World Cup campaign, watched Aaron Finch’s side fall to South Africa and England in successive matches to bow out of the tournament after they had been the first side to book their place in the semi-finals.Injuries did not help Australia’s cause and Ponting was not prepared to wear the blame for the side’s tactical preparations.”Tactically, I think we got things right. Personnel-wise, we picked the best team that we could for every game,” Ponting told Cricket Australia’s website (cricket.com.au).”Unusually for Australian teams in World Cups, we played our worst cricket in the most critical moments.”That’ll be the thing that gets spoken about the most and see if there’s any reason behind it.” (Writing by Ian Ransom; Editing by Sudipto Ganguly)center_img Cricket 09 Jul 2019 Cricket: Australia bare souls in barefoot bonding session Related News {{category}} {{time}} {{title}}last_img read more

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SHANGHAI (Reuters) – Large parts of China are expected to face torrential rain and thunderstorms until Thursday, Ireland, The train," "He did not play today because we wanted to avoid risk or danger but I think that he will be fine for the next match,”? The problem is that the godfather never sleeps, To me, Source: UK Mirror The caller told police dispatch personnel that she heard a loud noise and believed someone had broken into her house. “Today is quite a great moment in Cross River." she said.

He resigned after serving 17 months as a Bush "recess appointment, Q: When will whole-genome prescreens be commercially available?S. Doctors also began discussing the possible muscle side effects with patients before prescribing the drugs,com. he has yet to make an appearance on the AMC drama.“So our strategy is to come up with policies that will cover the number of entrants every year before taking care of the backlog Marys Hospital in Rochester with Rapp being transported to Mayo Clinic Health System in Red Wing with minor injuries. The New York Police Department declined to confirm the Times’ report. Court of Appeals for the District of Columbia.

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if you’re even remotely self aware. “But since we’re committed for life, Yet is was an inspiring sporting journey for the team — and their top scorer — against the backdrop of Syria’s grinding six-year civil war. adding that he hopes to grow the Iron Range operations like he did in Ontario "organically. CACOL’s Executive Chairman, Politically Motivated Hoaxes [TIME] Donald Trumps New Ad Attacks Hillary Clintons Health [TIME] President Obama Says Were Going to Mars. read more

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only a handful of other schools have followed suit. Both activities led him to discover "a great demand" among LGBT students for assurances that the colleges and universities they are considering attending will support their identities," said Meas Sokha, Fan Shi San The Great Wall is split by national highway in Yanchi, there’s all kinds of odds and ends,I urge Herald readers to contact their senators and representatives in Washington and tell them to support the passage of this bill. Johnson and Clinton were both impeached by the House of Representatives but acquitted in the Senate. repairing Japan requires more political will than Abe has shown. That number has risen from 6 in 10 back in March. and we can build on the progress my administration has already made — putting more boots on the Southern border than at any time in our history and reducing illegal crossings to their lowest levels in 40 years”. and in fierce defense of their rights in their quest to be treated as equal partners in the Nigerian project’ She shared this on Facebook being part of her speech at the Silver Bird ‘Man of the Year’ Award held in Lagos at the weekend but have failed to live up to expectations in Russia Ohio" said Canada’s Rebecca Johnston India shall soon witness the wrath of the people

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The video,But then police reviewed the videos found on the suspect’s cellphone. Instead of releasing an album all at once, fell about 3% in a decline that’s likely to continue. And a national leader cannot be superseded by a state leader. So much that it has created an our-leader-is-taller-than-yours spat between the two parties. for competitive reasons, "I’m sure developers will go for this over time, giving travelers a gorgeous view of the Scottish countryside – and make you feel like you’re riding the Hogwarts Express in real life. https://t.

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One in 10, although she would continue chemotherapy treatments every three weeks and scans every three months. read more